Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-256-3 | CAS number: 21178-63-2
Endpoint summary
Administrative data
Description of key information
Skin: not irritating (BASF AG, 1990)
Eye: not irritating (BASF AG, 1990)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation:
Three Vienna White rabbits received application of about 0.5 ml test item onto the shaved skin for 4 hours under semi-occlusive conditions (BASF AG, 1990) according to OECD 404 guideline; the animals were observed for skin reaction during 8 days. Readings were done at time point 24, 48 and 72 hours. Scoring of the skin findings was based on the scoring system outlined in OECD 404 guideline. The mean erythema score (24/48/72 hours) was 0.8 (0.3 in 2/3 animals, 1.7 in 1/3 animals) and was completely reversible within 8 days. No edema was seen in 2/3 animals, the third animal had a mean score (24/48/72 hours) of 0.3 leading to an overall mean of 0.1 in the three animals. The edema in the one animals was fully reversible within 48 hours. Thus the item was not irritating to the skin of rabbits under the test conditions chosen.
Eye irritation:
A eye irritation study according to OECD 405 guideline was performed (BASF AG, 1990). Three white rabbits (vienne white and new zealand white) were used. The test substance (0.1 ml) was applied undiluted into the conjunctival sac of one eye of the animals. Readings for eye irritation findings were performed 1, 24, 48 and 72 h as well as 8 or 9 d after test substance application. The mean cornea score (24/48/72 hours) was 0, the mean iris score (24/48/72 hours) was also 0. The mean score for redness of the conjunctivae (24/48//2 hours) was 1.3 (1/3 animals with 1.7, 1/3 animals with 1.3 and 1/3 animals with 1.0) and the mean score for edema (24/48/72 hours) was 0.6 (1/3 animals with 1.3, 1/3 animals with 0.3 and 1/3 animals with 0). All findings were fully reversible within 8 -9 days. Thus, the test item was not irritating to the eye of rabbits under the test conditions chosen.
Justification for classification or non-classification
Since the test item was neither irritant to the skin nor to the eye according to current scoring criteria, there is no need for classification according to the EU Directive 67/548/EC and according to the CLP Regulation 1272/2008 .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
