Registration Dossier
Registration Dossier
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EC number: 201-837-6 | CAS number: 88-51-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Comparatively little details are reported. Only ten animals were used in the treatment groups. However, the exposure conditions used are rather stringent.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium 4-amino-6-chlorotoluene-3-sulphonate
- EC Number:
- 229-596-2
- EC Name:
- Sodium 4-amino-6-chlorotoluene-3-sulphonate
- Cas Number:
- 6627-59-4
- IUPAC Name:
- sodium 2-amino-4-chloro-5-methylbenzenesulfonate
- Details on test material:
- - Molecular formula (if other than submission substance): C7H8ClNO3S.Na
- Molecular weight (if other than submission substance): 244.65
- Smiles notation (if other than submission substance): Cc1cc(c(N)cc1Cl)S(O)(=O)=O
- InChl (if other than submission substance): 1S/C7H8ClNO3S/c1-4-2-7(13(10,11)12)6(9)3-5(4)8/h2-3H,9H2,1H3,(H,10,11,12)
- Substance type: solid
- Analytical purity: indicated as "pure"
The substance is the sodium salt of the registered substance.
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: acetone
- Concentration / amount:
- 2% and saturated (induction)
2% (challenge)
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: acetone
- Concentration / amount:
- 2% and saturated (induction)
2% (challenge)
- No. of animals per dose:
- 10
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Executive summary:
None of the 10 treated guinea pigs showed skin reactions after challenge.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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