Registration Dossier
Registration Dossier
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EC number: 206-743-9 | CAS number: 372-09-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study with limited documentation.
Data source
Reference
- Reference Type:
- grey literature
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
- Principles of method if other than guideline:
- (according to US EPA DOT, 49 CFR, GLP
- GLP compliance:
- yes
Test material
- Reference substance name:
- Cyanoacetic acid
- EC Number:
- 206-743-9
- EC Name:
- Cyanoacetic acid
- Cas Number:
- 372-09-8
- Molecular formula:
- C3H3NO2
- IUPAC Name:
- cyanoacetic acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
Any other information on results incl. tables
Local irritant effects on the skin and some systemic effects (dyspnea, behavioral changes) were reported, indicating a possible systemic toxicity after dermal exposure.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In this study, with limited documentation, local irritant effects on the skin and some systemic effects (dyspnea, behavioral changes) were reported, indicating a possible systemic toxicity after dermal exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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