Registration Dossier
Registration Dossier
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EC number: 700-589-0 | CAS number: 1369492-52-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The test substance is with high probability acutely not harmful to algae. No toxic effects occur within the range of water solubility.
Key value for chemical safety assessment
Additional information
Acute toxicity of the mixture to aquatic organisms is derived from ecotoxicological information about the end-product and the by-product.
One GLP study according to OECD guideline 201 (1984) was performed with the end-product (including the impurity exceeding 1%). The test solutions reduced growth rate of the fresh water algae species significantly, but no toxic effects occurred within the range of solubulity. The EC50 (72h) was determined to be 47 mg/l (nominal concentration).
A non-GLP static test was performed with the by-product for 24 h (method not available). After 24 h of exposure, the EC50 was found to be 245 g/L.
Toxicity to algae is therefore not predicted for the test substance.
Reasons for read-across:
The substance was not tested for short-term toxicity to algae. The test substance is a mixture which consists mainly of the end-product (approximately 50%) and a by-product (approximately 30%) as well as of different impurities and isomers of the end-product (one exceeding 1%). Therefore, information about short-term toxicity to algae are derived from studies performed respectively with the end-product and the major by-product.
Performance and
observations:
A
GLP-compliant study was performed according to OECD guideline 201 (1984)
with Selenastrum capricornutum. A homogenous dispersion of 100
mg/L of the end-product (including the impurity exceeding 1%) was
prepared. It was diluted and then filtered. The test solutions showed a
dose-dependent yellow color. Exponentially growing algae
were treated for 72h. The test solutions inhibited the growth of algae
because it colors the water and absorbs
the light. However, the EC50 (= 47 mg/L, nominal concentration) was
determined to be above the water solubility of the end-product. In
addition, the EC0 value (> 10 mg/L) is also clearly above the water
solubility.
The end-product is therefore considered with high probability acutely not harmful to aquatic algae since no toxic effects occur within the range of water solubility.
Short-term toxicity of the by-product was evaluated in one non-GLP study (method not available) with Chlorella vulgaris. The EC50 (24h) was determined to be 245 g/L.
Discussion:
The
by-product is not toxic to algae over an exposure period of 24h. The
end-product did not induce toxic effects to algae within its range of
solubility.
Toxic effects to algae are therefore not predicted for the test substance.
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