Registration Dossier
Registration Dossier
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EC number: 210-676-0 | CAS number: 621-29-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- m-tolyl isocyanate
- EC Number:
- 210-676-0
- EC Name:
- m-tolyl isocyanate
- Cas Number:
- 621-29-4
- Molecular formula:
- C8H7NO
- IUPAC Name:
- 1-isocyanato-3-methylbenzene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: paraffinic oil
- Controls:
- not specified
- Amount / concentration applied:
- 1 ml of 10% solution in paraffinic oil
- Duration of treatment / exposure:
- 1 hour
- Observation period:
- 24 hours
48 hours
14 days
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 hours, 7 days, 14 days
- Score:
- >= 6 - <= 7
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- 24 hours - all exposed skin white, tumorous, dried
48 hours - tumidness reduced, skin dried and congested
7 days - skin slough, congestion
14- days - blisters
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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