Registration Dossier
Registration Dossier
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EC number: 210-676-0 | CAS number: 621-29-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- m-tolyl isocyanate
- EC Number:
- 210-676-0
- EC Name:
- m-tolyl isocyanate
- Cas Number:
- 621-29-4
- Molecular formula:
- C8H7NO
- IUPAC Name:
- 1-isocyanato-3-methylbenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- weight 110 - 150 g
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1.259 ml/kg
1.585 ml/kg
1.995 ml/kg
2.512 ml/kg
3.163 ml/kg
3.981 ml/kg - No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 1.757 - <= 2.528 mL/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- 2.107 mL/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 1 868 - <= 2 687 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- 2 240 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1.259 ml/kg 1:10 (1 dead from 10 animals)
1.585 ml/kg 4:10
1.995 ml/kg 4:10
2.512 ml/kg 6:10
3.163 ml/kg 7:10
3.981 ml/kg 10:10
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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