Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-350-4 | CAS number: 105-99-7
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Short summary of results; russian translation
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Astapova, S.A. et al.
- Year:
- 1 990
- Bibliographic source:
- Gigiena i sanitarija 55: 86
Materials and methods
- Principles of method if other than guideline:
- Mice are continuously exposed to vapours of the test substance for 24h/day over a period of 4 months.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dibutyl adipate
- EC Number:
- 203-350-4
- EC Name:
- Dibutyl adipate
- Cas Number:
- 105-99-7
- Molecular formula:
- C14H26O4
- IUPAC Name:
- 1,6-dibutyl hexanedioate
- Details on test material:
- - Name of test material (as cited in study report): DBA
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- gas chromatography
- Duration of treatment / exposure:
- 4 months
- Frequency of treatment:
- continuous treatment (24 h/day; 7 days/week)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5.0 ± 0.1, 0.45 ± 0.02 and 0.044 ± 0.003 mg/m³ air
Basis:
analytical conc.
- No. of animals per sex per dose:
- no data
Results and discussion
Results of examinations
- Details on results:
- The same LIMch (limit dose after chronic exposure) was derived for mice treated under the same conditions as the rats in this study.
Effect levels
- Dose descriptor:
- other: LIMch
- Effect level:
- 0.45 mg/m³ air (analytical)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: change in reflex activity; barriere change of neuromuscular stimulation: LIMac = 4.8 mg/m³
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
