Registration Dossier
Registration Dossier
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EC number: 203-350-4 | CAS number: 105-99-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List IV
- Author:
- Smyth, H.F. Jr., et al.
- Year:
- 1 951
- Bibliographic source:
- Arch Ind Hyg Occup Med 4(2):119-22
- Reference Type:
- publication
- Title:
- The place of the range findings test in the industrial toxicology laboratory
- Author:
- Smyth, H.F. Jr. and Carpenter, C.P.
- Year:
- 1 944
- Bibliographic source:
- as cited in: Journal of industrial hygiene and toxicology 26 (8): 269-273
- Reference Type:
- secondary source
- Title:
- Diesters Category of the Aliphatic Esters Chemicals (Test Plan and Robust Summaries for Substances in the HPV Test Plan)
- Author:
- US-EPA (American Chemistry Council's Aliphatic Esters Panel)
- Year:
- 2 010
- Bibliographic source:
- High Production Volume (HPV) Chemical Challenge Program (201-16837A and 201-16837B)
Materials and methods
- Principles of method if other than guideline:
- Application of a single oral dose to rats.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Dibutyl adipate
- EC Number:
- 203-350-4
- EC Name:
- Dibutyl adipate
- Cas Number:
- 105-99-7
- Molecular formula:
- C14H26O4
- IUPAC Name:
- 1,6-dibutyl hexanedioate
- Details on test material:
- - Name of test material (as cited in study report): Dibutyl adipate
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Additional information on strain: albino Wistar strain rats (or if necessary rats of other strains, as previously reported by the authors (1944))
- Weight at study initiation: 90 - 120 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
6 male rats were given a single dose of the test substance. One week later six more animals were given some other dosage and this procedure was repeated until two dosages differing by a multiple of ten were found one of which kills some or all animals and the other of which kills some or no animals within 14 days. An LD50 was then estimated on the assumption that the slope of a probit mortality vs. log dosage curve is the same as that of some structurally similar material which has been studied in more detail previously.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 12 900 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 6.6 - < 17
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
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