Registration Dossier
Registration Dossier
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EC number: 430-010-4 | CAS number: 12160-44-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The water solubility of the test substance is very low. The test media were analysed for iron content in order to demonstrate equilibration and stability of iron potassium oxide during the tests. Throughout the test no dissolved iron was detected at or above the Iimit of determination of 0.1 mg/L at the single loading rate of 1000 mg/L. No mortality or any other effects were noted in Daphnia magna exposed for 48 hours to a WAF prepared at a loading rate of 1000 mg/L. Therefore, an LC50 value cannot be reliably determined from the test. According to REACH guidance R7a (Appendix 7.8-1) for substances that show no effect at the limit of solubility, and for which all reasonable efforts were made to obtain and maintain the highest possible concentration over the whole test duration, the limit value is to be used for risk assessment. As these criteria were met, the 48-h EC50 for aquatic invertebrates is determined at >1.0 mg/L (limit of solubility).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 mg/L
Additional information
Acute toxicity to aquatic invertebrates was determined in a limit test performed according to the OECD guideline 203 and in compliance with GLP criteria. As the test substance was sparingly soluble in water, a water accommodated fraction was produced using a loading rate of 1000 mg/L. Daphnia magna (10 per concentration) were exposed to the test medium and a control for 48 hours under static conditions. Samples for analysis of the actual concentration were taken at the start of the test and after 48 hours. At the loading rate of 1000 mg/L, analytical concentrations of dissolved iron were below the Iimit of detection (0.1 mg/L) in all. The concentration of suspended iron was appr. 0.4 mg/L at the start and end of the study. No immobilisation of Daphnids or other toxic effects were noted at 24 and 48 hours. Based on these findings the 48-h EC50 is determined at > 1000 mg/L (based on the loading rate).
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