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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data from authoritative databases

Data source

Referenceopen allclose all

Reference Type:
other: Authoritative data base
Title:
Determination of Eye Irritation Potential of the test chemical
Author:
IFA (GESTIS)
Year:
2011
Bibliographic source:
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften); 2011
Reference Type:
other: Secondary study
Title:
Eye irritation study of test substance
Author:
U. S. Environmental Protection Agency
Year:
2018
Bibliographic source:
High Production Volume (HPV) Challenge Program; 2018
Reference Type:
other: Secondary source
Title:
Eye irritation study
Author:
IUCLID Dataset
Year:
2000
Bibliographic source:
EUROPEAN COMMISSION – European Chemicals Bureau; 19–FEB–2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation potential of the test chemical
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N-diethylaniline
EC Number:
202-088-8
EC Name:
N,N-diethylaniline
Cas Number:
91-66-7
Molecular formula:
C10H15N
IUPAC Name:
N,N-diethylaniline
Test material form:
liquid
Remarks:
Oily liquid
Details on test material:
- Name of test material (as cited in study report): N,N-Diethylaniline
- Molecular formula: C10-H15-N
- Molecular weight: 149.236 g/mol
- Smiles notation: c1(N(CC)CC)ccccc1
- InChl: 1S/C10H15N/c1-3-11(4-2)10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3
- Substance type: Organic
- Physical state: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
100%
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Duration of post- treatment incubation (in vitro):
no data
Number of animals or in vitro replicates:
no data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: not specified
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation was observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The test material did not induce any ocular effects. Hence the test chemical was considered to be not irritating to the eyes of treated rabbits.
Executive summary:

The ocular irritation potential of the test chemical was in rabbits according to OECD Guide–line 405 "Acute Eye Irritation/Corrosion"

 

When the undiluted test chemical was instilled into the eyes of each rabbit, no adverse effects were observed in treated eyes.

 

Since the test material did not induce any ocular effects, the test chemical was considered to be not irritating to the eyes of treated rabbits.