Registration Dossier
Registration Dossier
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EC number: 482-410-3 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
A toxicokinetic assessment of the pentaeryhtritol esters family (of which Hatcol 1760 is a member) was prepared.
A high LD50 was observed in the acute oral study (>2000 mg/kg). The subacute toxicity test for 28 -days revealed a NOAEL (for male rats) of 250 mg/kg/day. Therefore, an extensive toxicokinetic assessment is considered of limited value.
Hatcol 1760 has a low water solubility and a high partition coefficient. It is expected that the oral bioavailabilitty and thus systenic exposure will be relatively low. It is not expected to penetrate the skin easily because of it's high Pow, and uptake via inhalation is unlikely because of it's relatively large particle size.
Based on the expected kinetic behavious in the body, Hatcol 1760 will hardly be absorbed after oral administration, mainly because of its low water solubility. If absorption occurs, it will be extensively metabolised in the liver or plasma and rapidkly expcreted via bile and/or urine. Therefore, accumulation in the body during prolonged exposure will be very low, although some retention in fatty tissues may occur.
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