Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 809-434-2 | CAS number: 609783-45-1
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 Mar- 01 Apr 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- January 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 4-Amino-2-fluoro-benzamide
- EC Number:
- 809-434-2
- Cas Number:
- 609783-45-1
- Molecular formula:
- C7H7FN2O
- IUPAC Name:
- 4-Amino-2-fluoro-benzamide
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 8.33 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 6.5
- Details on results:
- The results showed no tendency to increase and the deviation between the incubation times was below 15 %, therefore a valid conduct of the study can be considered.
Corresponding to the analyses the water solubility was determined to be
pH level tested: 6.5
average concentration: 8.33 g/L
tendency to in-/decrease: no
relative standard deviation: 3.1%
demanded max. range( Guideline 105): <15%
Number of replicates: 6
at a temperature of 20 ± 0.4 °C.
Any other information on results incl. tables
| sample description | pH after incubation | age | concentration [mg/L] |
| sample 72h_Rep 1 | 6.5 | 24 | 8571.597 |
| sample 72h_Rep 2 | 6.5 | 24 | 8513.653 |
| sample 48h_Rep 1 | 6.5 | 48 | 7941.659 |
| sample 48h_Rep 2 | 6.5 | 48 | 8095.198 |
| sample 24h_Rep 1 | 6.5 | 72 | 8501.386 |
| sample 24h_Rep 2 | 6.5 | 72 | 8369.674 |
Applicant's summary and conclusion
- Conclusions:
- Corresponding to the analyses the water solubility was determined to be
pH level tested: 6.5
average concentration: 8.33 g/L
tendency to in-/decrease: no
relative standard deviation: 3.1%
demanded max. range( Guideline 105): <15%
Number of replicates: 6
at a temperature of 20 ± 0.4 °C. - Executive summary:
The water solubility of the test item was determined using the shake flask method. The saturation mass concentrations of the test item were determined using U-HPLC / UV - determination.
The results showed no tendency to increase and the deviation between the incubation times was below 15 %, therefore a valid conduct of the study can be considered. Corresponding to the analyses the water solubility was determined to be
pH level tested: 6.5
average concentration: 8.33 g/L
tendency to in-/decrease: no
relative standard deviation: 3.1%
demanded max. range( Guideline 105): <15%
Number of replicates: 6at a temperature of 20 ± 0.4 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
