4-amino-2-fluorobenzamide

Boiling point

Administrative data

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24 Jan - 31 Jan 2022

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2022

Report date:

2022

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

1995

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

dynamic method

Remarks:

DSC

Test material

Test material information

Constituent 1

Reference substance name:

4-Amino-2-fluoro-benzamide

EC Number:

809-434-2

Cas Number:

609783-45-1

Molecular formula:

C7H7FN2O

IUPAC Name:

4-Amino-2-fluoro-benzamide

Results and discussion

Boiling point

Key result

Decomposition:

yes

Decomp. temp.:

290 °C

Remarks on result:

other:

Any other information on results incl. tables

DSC-measurements

During the heating phase a distinct endothermic effect was observed in the temperature range of 130 – 160 °C, which can be assigned to the melting of the test item. As the onset temperatures in both tests do not deviate by more than 0.5 K from their mean value of 145.70 °C, this temperature can be used as melting point. The test item has a melting point of 145.7 °C. The test item showed a second endothermic signal in the temperature range of
290 – 380 °C, which could not be clearly assigned to the boiling of the test item. Thus, the photo cell detection method was performed. In the capillary, the first large bubble rises at 273 °C. At the same time, the test item changes colour from a clear, yellowish liquid to an orange, light brown liquid. It is concluded that the test item decomposes simultaneously with the start of boiling. Based on visual observation in the BÜCHI Apparatus it is stated that the test item has no boiling point but starts to decompose at a temperature of 290 °C. No further thermal effects were observed up to the test end temperature of 500 °C.

Results of DSC-measuremets

Measurement No.	Sample weight [mg]	Onset of Effect [°C]	Range of effect [°C]	Weight loss [mg]	Atmospheric pressure [hPa]
1	8.70	145.70 318.56	130 - 160 (endo) 290 - 370 (endo)	5.89	1022.3
2	9.57	145.69 321.88	130 - 160 (endo) 290 - 370 (endo)	6.45	1023.4

Applicant's summary and conclusion

Conclusions:

The test item has no boiling point at atmospheric pressure (1022 - 1023 hPa) but starts to decompose at a temperature of 290 °C as determined by Differential Scanning Calorimetry and confirmed by the photo cell detection method.

Executive summary:

Test Design: The determination of the boiling point of the test item was performed using Differential Scanning Calorimetry (DSC).

Result: The test item has no boiling point at atmospheric pressure (1022 - 1023 hPa) but starts to decompose at a temperature of 290 °C as determined by Differential Scanning Calorimetry and confirmed by the photo cell detection method.