Registration Dossier
Registration Dossier
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EC number: 231-298-2 | CAS number: 7487-88-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- other:
- Title:
- ECHA disseminated Dossier of Magnesium sulfate (CAS 7487-88-9)
- Year:
- 2 022
- Bibliographic source:
- ECHA disseminated Dossier of Magnesium sulfate (CAS 7487-88-9), query date 2022-03-18
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Magnesium sulphate
- EC Number:
- 231-298-2
- EC Name:
- Magnesium sulphate
- Cas Number:
- 7487-88-9
- Molecular formula:
- H2O4S.Mg
- IUPAC Name:
- magnesium sulphate
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- propylene glycol
- Concentration:
- 10, 25, 50%
- No. of animals per dose:
- 5
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Value:
- >= 0.8 - <= 1.2
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Since there was no indication that the test substance elicit an SI ≥ 3 when tested up to 50%, the test substance was considered to be a non skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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