Registration Dossier
Registration Dossier
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EC number: 231-298-2 | CAS number: 7487-88-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- other: Published Assessment
- Title:
- SIDS Initial Assessment Profile for SIAM 31: Magnesium sulfate
- Author:
- OECD
- Year:
- 2 010
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Magnesium sulphate
- EC Number:
- 231-298-2
- EC Name:
- Magnesium sulphate
- Cas Number:
- 7487-88-9
- Molecular formula:
- H2O4S.Mg
- IUPAC Name:
- magnesium sulphate
Constituent 1
Test animals
- Species:
- rat
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 300 (1st and 2nd step) and 2,000 mg/kg (3rd and 4th step) bw
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Mortality:
- No deaths were observed.
- Clinical signs:
- diarrhoea
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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