N, N-bis-(2-hydroxyethyl) dimethyl ammonium methane sulfonate

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2021-02-02 to 2021-06-17

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

European Commission Regulation (EC) No. 440/2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Remarks:

Supplementary, the boiling point/range was determined by capillary tube in a metal block

Key result

Boiling pt.:

>= 280 °C

Atm. press.:

1 013 hPa

Decomposition:

yes

Decomp. temp.:

>= 280 °C

Boiling point / boiling range: DSC measurement
The first DSC measurement in an aluminium crucible with a hole showed an endothermal effect after the melting in the temperature range of 290– 325 °C, directly followed by an exothermal effect in the temperature range of 325 – 345 °C. The exothermal effect was in turn followed by an endothermal effect in the temperature range of 345 – 430 °C. Additionally, an endothermal effect was observed in the temperature range of 450 – 490 °C. The mass loss after the DSC measurements amounted to 92 %.
A second DSC measurement in an aluminium crucible with a hole showed an endothermal effect after the melting in the temperature range of 290 – 330 °C directly followed by an exothermal effect in the temperature range of 330 – 360 °C. Additionally, an endothermal effect was observed in the temperature range of 440 – 485 °C. The mass loss after the DSC measurements amounted to 95 %.
To clarify whether the test item first boils and then decomposes, or whether decomposition already starts at the beginning of boiling, a third DSC measurement in an aluminium crucible with a hole was performed up to a final temperature of 325 °C. Within this measurement an endothermal effect after the melting, starting at 270 °C and persisting through the final temperature of 325 °C was observed. The mass loss after the DSC measurement amounted to 24 %. After the DSC measurement, brown sample residues were observed in the crucible.
The results of the DSC measurements are summarized in the table 1 below:

Table 1: Boiling Point (DSC measurements)

Ident No.	Test item / mg	Starting temperature / °C	Final test temperature / °C	Temperature range / °C	Onset  (boiling)^1 / °C	Crucible	Observations after the measurement
39439	12.18	‑80	500	290 – 325 (endothermal) 325 – 345 (exothermal) 345 – 430 (endothermal) 450 – 490 (endothermal)	--	Aluminium with a hole	Black residue Mass loss: 92 %
39472	12.04	‑80	500	290 – 330 (endothermal) 330 – 360 (exothermal) 440 – 485 (endothermal)	--	Aluminium with a hole	Black residue Mass loss: 95 %
39494	39.05	‑80	325	270 – (> 325) (endothermal)	--	Aluminium with a hole	Brown sample residues. Mass loss: 24 %

Graphical presentations of the DSC runs are shown in Figure 1 and Figure 2 given in the illustration attached to this ESR.

Boiling point / boiling range: capillary tube in a metal block
A measurement with the capillary method was performed to clarify the results of the DSC measurements. Since this measurement was performed only as a verifying screening a high heating rate of 10 K/min was chosen and therefore the absolute temperature values derived with the capillary method are not as accurate as the DSC results. The filling height of the test item was approximately 5 mm. The results are summarized in Table 2 below:

Table 2: Results of the capillary method

No.	Set point / °C	Heating rate / K/min	End point / °C	Remarks
1	200	10	400	The test item was a brown-yellow viscous liquid. 281 °C: Beginning of bubbles and colour change to amber. 289 °C: Bubbling increased and further discolouration to dark. 307 °C: Continuous bubbling (boiling). 337 °C: Only few brown coloured test item left. Occasional bubble formation. 366 °C: Brown to black coloured test item. Very occasionally bubble formation.

The capillary method measurement showed that the test item boiled accompanied by a colour change (decomposition) within a wide temperature range.
Under consideration of the results from the DSC measurements and the capillary method, it was concluded that the test item boiled under decomposition starting at approx. 280 °C.

Conclusions:

Boiling range (OECD TG 103; A.2; DSC / Capillary method): >=280 °C under decomposition (>=280 °C)

Executive summary:

The boiling point (range) of the test item was determined compliant with GLP according to European Commission Regulation (EC) No. 440/2008, A.2. as well as OECD 103 (1995) at atmospheric conditions.
Initially, two independent Differential Scanning Calorimetry (DSC) runs were performed to assess the boiling point/range. Using a cooling / heating rate of 10 K/min in a temperature range of -80 °C to 500 °C, an endothermal peak around 317 °C followed an exothermal peak at ca. 354 °C again followed by an endothermal peak around 470 °C indicated an overlap between boiling and decomposition, as did the observed mass loss after the DSC measurements of 92 %. To clarify whether the test item first boils and then decomposes, or whether decomposition already starts at the beginning of boiling, a third DSC measurement in an aluminium crucible with a hole was performed up to a final temperature of 325 °C. Within this measurement, an endothermal effect starting at 270 °C and persisting throughout the final temperature of 325 °C was observed. The mass loss after the DSC measurement amounted to 24 %. After the DSC measurement, brown sample residues were observed in the crucible.
To clarify the results of the DSC measurements further, a measurement with the capillary method was performed, which showed that the test item boiled accompanied by a colour change (decomposition) within a wide temperature range with beginning of bubbles and colour change to amber at 281 °C. At 289 °C bubbling increased, and a further discolouration to dark was observed.
Under consideration of the results from the DSC measurements and the capillary method, it was concluded that MAT-144 boiled under decomposition starting at approx. 280 °C at atmospheric conditions. 

Description of key information

Boiling range (OECD TG 103; A.2; DSC / Capillary method): >=280 °C under decomposition (>=280 °C)

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

280 °C

Temperature of decomposition (state purity):

280 °C

Additional information

The boiling point (range) of the test item was determined compliant with GLP according to European Commission Regulation (EC) No. 440/2008, A.2. as well as OECD 103 (1995) at atmospheric conditions.
Initially, two independent Differential Scanning Calorimetry (DSC) runs were performed to assess the boiling point/range. Using a cooling / heating rate of 10 K/min in a temperature range of -80 °C to 500 °C, an endothermal peak around 317 °C followed an exothermal peak at ca. 354 °C again followed by an endothermal peak around 470 °C indicated an overlap between boiling and decomposition, as did the observed mass loss after the DSC measurements of 92 %. To clarify whether the test item first boils and then decomposes, or whether decomposition already starts at the beginning of boiling, a third DSC measurement in an aluminium crucible with a hole was performed up to a final temperature of 325 °C. Within this measurement, an endothermal effect starting at 270 °C and persisting throughout the final temperature of 325 °C was observed. The mass loss after the DSC measurement amounted to 24 %. After the DSC measurement, brown sample residues were observed in the crucible.
To clarify the results of the DSC measurements further, a measurement with the capillary method was performed, which showed that the test item boiled accompanied by a colour change (decomposition) within a wide temperature range with beginning of bubbles and colour change to amber at 281 °C. At 289 °C bubbling increased, and a further discolouration to dark was observed.

Under consideration of the results from the DSC measurements and the capillary method, it was concluded that MAT-144 boiled under decomposition starting at approx. 280 °C at atmospheric conditions.