Registration Dossier
Registration Dossier
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EC number: 210-933-7 | CAS number: 626-17-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 October 2019 - 31 October 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- GLP study to current guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Test substance name: Isophthalonitrile
Chemical name: 1,3-dicyanobenzene
CAS number: 626-17-5
EC number: 210-933-7
LOT number: JB1906150101
Purity: 99.8 % (w/w %)
Appearance: Off white solid flakes
Manufacture date: 15 June 2019
Expiry date: 15 June 2020
Storage condition: Room temperature (15-25oC. below 70 RH%), protected from humidity
Safety Precautions: Routine safety precautions for unknown materials (lab coat. mask. gloves and safety glasses) were applied to assure personnel health and safety. - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.5
- Temp.:
- 25 °C
- Remarks on result:
- other: pHvalue not stated
- Details on results:
- The retention time measured for Isophthalonitrile (2.245 min) shows that log Pow of the test item is within the calibrated log Pow range. Based on the regression equation, the log Pow of Isophthalonitrile was calculated as 1.5.
- Conclusions:
- The retention time measured for Isophthalonitrile (2.245 min) shows that log Pow of the test item is within the calibrated log Pow range. Based on the regression equation, the log Pow of Isophthalonitrile was calculated as 1.5.
- Executive summary:
In the course of this study the partition coefficient (log Pow) of Isophthalonitrile was estimated using the HPLC method (OECD 117). The estimated log Pow of the test item was given to be 1.5.
Reference
Description of key information
In the course of this study the partition coefficient (log Pow) of Isophthalonitrile was estimated using the HPLC method (OECD 117). The estimated log Pow of the test item was given to be 1.5.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.5
- at the temperature of:
- 25 °C
Additional information
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