Registration Dossier
Registration Dossier
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EC number: 234-232-0 | CAS number: 10605-21-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Acclimatisation period, housing and feeding conditions are not reported. The body weight was not determined.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Carbendazim
- EC Number:
- 234-232-0
- EC Name:
- Carbendazim
- Cas Number:
- 10605-21-7
- Molecular formula:
- C9H9N3O2
- IUPAC Name:
- carbendazim
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Doses:
- single dose suspended in aqueous CMC/cremophor EL.
The dose levels were 1600, 3200 and 6400 mg/kg bw. - No. of animals per sex per dose:
- 3 groups of 5 male and 5 female rats.
Source Gassner Co., Sulzfeld, Germany - Details on study design:
- Mortality was evaluated at 1, 24 and 48 hours as well as 7 and 14 days after administration.
- Statistics:
- None.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One female found dead at the highest dose level after 14 days.
- Clinical signs:
- other: No clinical signs were noted.
- Gross pathology:
- No macroscopic anomalies.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral toxicity (LD50 14d) was above 6400 mg/kg bw. Although one female died at the highest dose level, no clinical signs and pathological changes were observed. It is supposed that the death occurred was not related to the treatment.
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