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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

Currently viewing:

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
GLP compliance:
yes
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 1% w/v aqueous solution of methyl cellulose
Duration of treatment / exposure:
28 days
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
250.0 and 1000.0 mg/kg/day
Basis:
other: prepared in 1% w/v aqueous solution of methyl cellulose
No. of animals per sex per dose:
female: 10 animals at 0 mg/kg bw/day
female: 5 animals at 250 mg/kg bw/day
female: 10 animals at 1000 mg/kg bw/day
male: 10 animals at 0 mg/kg bw/day
male: 5 animals at 250 mg/kg bw/day
male: 10 animals at 1000 mg/kg bw/day

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion