Iron, bis(glycinato-.kappa.N,.kappa.O)-

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2020

Reliability:

1 (reliable without restriction)

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

GLP compliance:

yes (incl. QA statement)

Analytical monitoring:

yes

Preliminary study:

Hydrolysis of Iron Glycinate was conducted at 50 ± 0.5°C in buffer pH 4, 7 and 9 buffer solutions for a period of 5 days.

Test performance:

Based on the test results Iron Glycinate was found hydrolytically stable in buffer pH 4, pH 7 and 9
buffers at 50C ± 0.5°C.

Transformation products:

no

pH:

9

Temp.:

50

DT50:

>= 1 yr

Type:

(pseudo-)first order (= half-life)

pH:

7

Temp.:

50 °C

DT50:

> 1 yr

Type:

(pseudo-)first order (= half-life)

pH:

4

Temp.:

50 °C

DT50:

> 1 yr

Type:

(pseudo-)first order (= half-life)

Validity criteria fulfilled:

yes

Conclusions:

On the basis of test results, the test item was not hydrolyzed in buffer pH 4, pH 7 and pH 9 when stored at 50 ± 0.5ºC for 5 days. The test item was considered as hydrolytically stable in buffer pH 4, pH 7 and pH 9 buffers. It concludes that the test item half-life is greater than 1 year (t1/2 >1 Year) in buffer pH 4, pH 7 and pH 9.

Description of key information

On the basis of test results, the test item was not hydrolyzed in buffer pH 4, pH 7 and pH 9 when stored
at 50 ± 0.5ºC for 5 days. The test item was
considered as hydrolytically stable in buffer pH 4, pH 7 and pH 9 buffers. It concludes that the test item
half-life is greater than 1 year (t1/2 >1 Year) in buffer pH 4, pH 7 and pH 9.

Key value for chemical safety assessment

Half-life for hydrolysis:

1 yr

at the temperature of:

50 °C