Registration Dossier
Registration Dossier
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EC number: 212-506-0 | CAS number: 822-89-9
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 May - 16 June 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EPA/FIFRA Subdivision D § 63-8
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- Hydroxyl-2-pyridone
- EC Number:
- 212-506-0
- EC Name:
- Hydroxyl-2-pyridone
- Cas Number:
- 822-89-9
- Molecular formula:
- C5H5NO2
- IUPAC Name:
- 1-hydroxy-1,2-dihydropyridin-2-one
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study reports): Oxy PYRION
- Physical state: solid (powder)
- Appearance: white crystalline powder
Constituent 1
- Specific details on test material used for the study:
- - Batch n°: 93100020
- Analytical purity: not reported
- Expiration date: not reported
- Storage condition: not reported
Results and discussion
Water solubilityopen allclose all
- Key result
- Water solubility:
- 61.1 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 25 °C
- pH:
- 5.01
- Key result
- Water solubility:
- 239 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 25 °C
- pH:
- >= 7.04 - <= 7.05
- Key result
- Water solubility:
- 47.4 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 25 °C
- pH:
- >= 3.63 - <= 3.65
- Remarks on result:
- other: Purified water
- Key result
- Water solubility:
- > 500 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 25 °C
- pH:
- 9.04
- Details on results:
- Preliminary test
The solubility of the test substance in purified water and pH 5 buffer was determined to be between 22 and 54 g/L, in pH 7 buffer between 250 and 510 g/L and in pH9 buffer > 500 g/L. A full solubility test at pH 9 was not performed due to the high solubility of the compound and the difficulty encountered when trying to maintain the pH at 9.
Main test
The results for the samples are given in the table underneath.
Any other information on results incl. tables
| Samples | Analysed concentration (g/L) |
| purified water | 45.2 g/kg of solution |
| purified water | 47.4 g/L of water |
| pH 5 | 57.6 g/kg of solution |
| pH 5 | 61.1 g/L of buffer |
| pH 7 | 239 g/L solution |
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the test item at 25°C was determined to be 61.1 g/L at pH 5, 239 g/L at pH 7 and >500 g/L at pH 9.
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