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Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
yes
Principles of method if other than guideline:
additional pH value; pH1.2, 4h, 40^C; only pre tests at 50°C, because hyrolysis less 10%
GLP compliance:
no
Specific details on test material used for the study:
se attached study report
Radiolabelling:
no
Analytical monitoring:
yes
Details on sampling:
se attached study report
Buffers:
se attached study report
Estimation method (if used):
-
Details on test conditions:
se attached study report
Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
ca. 20 g/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
20 g/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
20 g/L
Duration:
4 h
pH:
1.2
Temp.:
40 °C
Initial conc. measured:
20 g/L
Number of replicates:
1
Positive controls:
no
Negative controls:
no
Statistical methods:
-
Preliminary study:
no hydroysis
Test performance:
see attached report
Transformation products:
not measured
Remarks:
basedon no relevant hydrolysis at all tested pH
pH:
4
Temp.:
50 °C
Duration:
5 d
Remarks on result:
hydrolytically stable based on preliminary test
pH:
7
Temp.:
50 °C
Duration:
5 d
Remarks on result:
hydrolytically stable based on preliminary test
pH:
9
Temp.:
50 °C
Duration:
5 d
Remarks on result:
hydrolytically stable based on preliminary test
pH:
1.2
Temp.:
40 °C
Duration:
4 h
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
4
Temp.:
50 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
7
Temp.:
50 K
DT50:
> 1 yr
Type:
not specified
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
9
Temp.:
50 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
1.2
Temp.:
40 °C
DT50:
> 4 h
Type:
not specified
Remarks on result:
hydrolytically stable based on preliminary test
Validity criteria fulfilled:
yes
Conclusions:
At all ph´s no relevant hydroysis

Description of key information

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
20 °C

Additional information