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EC number: 240-610-6 | CAS number: 16545-00-9
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
Test material
- Reference substance name:
- Bis[2-(diethylamino)ethyl] adipate
- EC Number:
- 240-610-6
- EC Name:
- Bis[2-(diethylamino)ethyl] adipate
- Cas Number:
- 16545-00-9
- Molecular formula:
- C18H36N2O4
- IUPAC Name:
- 1,6-bis[2-(diethylamino)ethyl] hexanedioate
- Reference substance name:
- 2-diethylaminoethanol
- EC Number:
- 202-845-2
- EC Name:
- 2-diethylaminoethanol
- Cas Number:
- 100-37-8
- Molecular formula:
- C6H15NO
- IUPAC Name:
- 2-(diethylamino)ethanol
- Test material form:
- liquid
Constituent 1
impurity 1
Results and discussion
Vapour pressure
- Key result
- Test no.:
- #1
- Temp.:
- ca. 20 °C
- Vapour pressure:
- ca. 0 Pa
Any other information on results incl. tables
The following vapour pressures were determined experimentally and considered as valid (mean and standard deviation given):
Table 10-a Experimentally Determined Vapour Pressures
T |
T |
P |
Stand. Dev. P |
RSD P |
°C |
K |
Pa |
Pa |
% |
45.0 |
318.2 |
8.33E-03 |
1.99E-04 |
2.4% |
60.0 |
333.2 |
4.90E-02 |
4.95E-03 |
10.1% |
75.0 |
348.2 |
2.24E-01 |
8.24E-03 |
3.7% |
90.0 |
363.2 |
8.89E-01 |
8.57E-02 |
9.6% |
In this table, E-0X represents multiplication with 10-X.
Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation
For the test itemBis[2-(diethylamino)ethyl]adipate, the following vapour pressures at 20°C and at 25°C were calculated from the regression equation:
Vapour pressure at 20°C: |
3.45* 10-04Pa |
Vapour pressure at 25°C: |
6.85* 10-04Pa |
The linear regression of log P vs. 1/T gave a correlation coefficient r of - 0.9998, showing good repeatability and precision. Therefore, the determination is considered as valid.
1 Discussion
The vapour pressure of the test itemBis[2-(diethylamino)ethyl]adipatewas determined at five different temperatures (30, 45, 60, 75 and 90°C) following EU A.4 using the effusion method (weight loss). The first experiment (nominal temperature 30 °C) yielded no reproducible weight loss. Therefore these values were not used for calculation.
Four experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 11 % and good correlation.
Therefore, the result of the test can be considered valid.
Applicant's summary and conclusion
- Conclusions:
- For the test item Bis[2-(diethylamino)ethyl]adipate, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:
Vapour pressure at 20 °C: 3.45* 10-04 Pa
Vapour pressure at 25 °C: 6.85* 10-04 Pa - Executive summary:
The vapour pressure of Bis[2-(diethylamino)ethyl]adipate was determined following EU A.4 using the effusion method (weight loss).
Vapour pressure was examined at five different temperatures. Four temperaturescould be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P).
Table3‑a Vapour Pressures (Effusion Method)
Experiment
T
Mean P
Stand. Dev. P
RSD P
No.
K
Pa
Pa
%
1
318.2
8.33E-03
1.99E-04
2.4%
2
333.2
4.90E-02
4.95E-03
10.1%
3
348.2
2.24E-01
8.24E-03
3.7%
4
363.2
8.89E-01
8.57E-02
9.6%
In this table, E-0X represents multiplication with 10-x.
Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation
The graph 1/T vs. log (P) shows a straight line with a correlation coefficient of - 0.9998.
For the test item Bis[2-(diethylamino)ethyl]adipate, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:
Vapour pressure at 20 °C: 3.45* 10-04 Pa
Vapour pressure at 25 °C: 6.85* 10-04 Pa
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