Registration Dossier
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EC number: 201-207-0 | CAS number: 79-43-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 106 mg/L
Additional information
In the publication from the Umweltbundesamt Germany (Trénel and Kuehn, 1982) an 24 h EC50 value of 2600 mg/L is reported for test solutions which were neutralized (as described in modern guidelines). If the test solution was not neutralized an 24h EC50 of 106 mg/L was found. This lower EC50 value of the non-neutralized approach was caused most likely by pH-effects. Therefore, this is not a toxic effect and hence, the result of the neutralized solution is more relevant for the risk assessment. The test duration deviates from the 48 hour test duration given in the more modern test guidelines. However, this EC50 value is so high that it is scientifically unrealistic to expect an immobilization which will have an impact on the risk assessment or classification and labelling from hour 24 to 48. Therefore this study is considered as reliable with restrictions and the EC50 from the neutralized test solution will be used for the risk assessment.
The relative low toxicity of DCA to daphnia is supported by a QSAR calculation using EPIwin which indicated that an 48h EC50 of 194 mg/L can be expected.
As a most conservative scenario, the EC50 from the non-neutralized test will be used for the risk assessment, i.e., the EC50 of 106 mg/L.
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