Registration Dossier
Registration Dossier
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EC number: 215-851-5 | CAS number: 1429-50-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1968
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The report was lacking in detail.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- [ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid
- EC Number:
- 215-851-5
- EC Name:
- [ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid
- Cas Number:
- 1429-50-1
- Molecular formula:
- C6H20N2O12P4
- IUPAC Name:
- [ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid
- Test material form:
- not specified
- Details on test material:
- No data.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or test system and environmental conditions:
- No data.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: corn oil. Also applied neat.
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): 25% solution-suspension in corn oil. Test substance was also applied neat as a finely ground powder. - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 'several days'
- Number of animals:
- 3 / dose
- Details on study design:
- No data.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24/48/72h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: as finely ground powder
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24/48/72h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: 25% suspension in corn oil
- Irritant / corrosive response data:
- No skin changes were noted when the compound was applied either in powder form or as a 25% solution-suspension in corn oil. All animals received a score of zero throughout the observation period.
- Other effects:
- None reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The compound was classed as non-irritating when applied as finely ground powder and as a 25% solution-suspension in corn oil to intact skin of male and female rabbits. The result is reported in a study which is similar to guideline but not compliant with GLP.
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