Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-851-5 | CAS number: 1429-50-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1968
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The number of animals tested per dose was one.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- Similar to version adopted in 1987
- Principles of method if other than guideline:
- The diluted compound was applied in increasing doses at increments of 0.2 fractional log intervals to the skin of the rabbits. Only one rabbit was tested per dose.
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- [ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid
- EC Number:
- 215-851-5
- EC Name:
- [ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid
- Cas Number:
- 1429-50-1
- Molecular formula:
- C6H20N2O12P4
- IUPAC Name:
- [ethane-1,2-diylbis[nitrilobis(methylene)]]tetrakisphosphonic acid
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: individual cages
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- corn oil
- Details on dermal exposure:
- No data.
- Duration of exposure:
- 24 hours
- Doses:
- 25% solution in corn oil at 501, 794, 1260, 2000, 3160, 5010 mg/kg
- No. of animals per sex per dose:
- 1 animal per dose, either male or female.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: no data
- Necropsy of survivors performed: no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 010 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no mortalities.
- Clinical signs:
- other: No real symptoms of acute toxicity were noted. Weakness was at a minimum and there was no nervousness.
- Gross pathology:
- No necropsy.
- Other findings:
- None reported.
Any other information on results incl. tables
The compound was not absorbed to any great extent.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- An acute dermal LD50 value of >5010 mg/kg was reported in a study which was conducted according to an appropriate test protocol, but not in compliance with GLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
