Registration Dossier
Registration Dossier
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EC number: 201-075-4 | CAS number: 78-00-2
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Type of information:
- read-across from similar mixture/product
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Reliability assessment as per that quoted in IUCLID 4 (2000) data review. Read across from supporting substance (structural analogue ot surrogate)
Data source
Reference
- Title:
- Chemical Induction of nondijunction in drosphilia
- Author:
- Ramel, C., Magnusson, J.
- Year:
- 1 979
- Bibliographic source:
- Environ. Health Persp. Vol 31, pp 59-66
Materials and methods
- Principles of method if other than guideline:
- Method: other outlined in publication
- GLP compliance:
- not specified
- Type of assay:
- Drosophila SLRL assay
Test material
- Reference substance name:
- Triethyllead chloride
- IUPAC Name:
- Triethyllead chloride
Constituent 1
Test animals
- Species:
- Drosophila melanogaster
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: feed
Doses / concentrations
- Dose / conc.:
- 16 mg/kg bw (total dose)
Results and discussion
Test results
- Sex:
- female
- Genotoxicity:
- ambiguous
- Toxicity:
- yes
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: ambiguous
- Executive summary:
- 16 mg Triel / L caused interference with meiotic nuclear division (chromosone segregation) in the offspring of female larvae of Drosophila melanogaster. The sex chromosomes were particularly affected, so that gametes with two X chromosomes (XXY individuals) occurred, while the distribution of the autosomes was not affected. From this it was deduced that TriEL has an effect on the spindle mechanism in the chromosome distribution to the daughter cells
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