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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
unknown
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Screening of Fluorine-Containing Compounds for Acute Toxicity
Author:
Smith FA, Downs WL, Hodge HC, Maynard EA
Year:
1960
Bibliographic source:
Toxicology and Applied Pharmacology 2, 54-58

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
- Principle of test: similar to up- and down-procedure
- Short description of test conditions: Graded series of doses were administered starting with a unit of 1 (mL, mg, g) and progressing upward or downward as determined by the results, using a factor of 3/2 if the dose was tolerated or 2/3 if the dose proved fatal.
- Parameters analysed / observed: mortality
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium hexafluorophosphate
EC Number:
241-143-0
EC Name:
Potassium hexafluorophosphate
Cas Number:
17084-13-8
Molecular formula:
F6P.K
IUPAC Name:
potassium hexafluoro-λ⁵-phosphanuide
Specific details on test material used for the study:
no specific details given

Test animals

Species:
mouse
Strain:
other: albino mice
Sex:
female
Details on test animals or test system and environmental conditions:
- Weight at study initiation: 20-30 g
- no further details given

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: either water, corn oil or propylene glycol; not precisely specified for the target compound
Details on exposure:
not reported
Doses:
Graded series of doses were administered starting with a unit of 1 (mL, mg, g) and progressing upward or downward as determined by the results, using a factor of 3/2 if the dose was tolerated or 2/3 if the dose proved fatal.
No. of animals per sex per dose:
2
Control animals:
not specified
Details on study design:
not described
Statistics:
not described

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
female
Dose descriptor:
other: maximal non-lethal dose
Effect level:
ca. 960 mg/kg bw
Based on:
test mat.
Key result
Sex:
female
Dose descriptor:
other: minimal lethal dose
Effect level:
ca. 1 120 mg/kg bw
Based on:
test mat.
Mortality:
At the minimal lethal dose of 1120 mg/kg bw, the two animals tested had died after 24 h.
Clinical signs:
not reported
Body weight:
not reported
Gross pathology:
not reported
Other findings:
not reported

Applicant's summary and conclusion

Conclusions:
The maximal non-lethal dose was determined to be in the range of 960 mg/kg bw and the minimal lethal dose in the range of 1120 mg/kg bw.
Executive summary:

In a toxicity study published by Smith et al. (1960), each two female albino mice were given potassium hexafluorophosphate intraperitoneally in a method using graded series of doses and observed for 24 h.

Hardly any details on experimental conditions are reported and the respective reference was not available. Thus, reliability was rated 4.

Maximal non-lethal dose= 960 mg/kg bw

Minimal lethal dose= 1120 mg/kg bw