Registration Dossier
Registration Dossier
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EC number: 203-430-9 | CAS number: 106-75-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Key value for chemical safety assessment
Additional information
Parent compound:
Results of a study on the effect of DIBIS (CAS 106 -75 -2) on Pseudomonas putida test are only available as secondary source in the review of BUA (1991). The original reference is not available; therefore, no details on the study are available. The following effect values were reported:
- 17-h EC10 = 69 mg/L (non-neutralised)
- 17 -h EC10 = 8070 mg/L (neutralised)
The study covers effects from the hydrolysis products diethylene glycol and HCl based on the long exposure duration and the short hydrolysis half-life of DIBIS (see IUCLID Ch. 4.7).
Hydrolysis product:
Diethylene glycol (DEG; CAS 111 -46 -6):
The effect of DEG on the respiration activity of activated sludge fro a wastewater treatment platn treating predominantly domestic sewage was investigated in two guideline studies. Klecka et al. (1985) determined a 3 -h EC50 of > 1000 mg/L in a study following OECD TG 209. In a study following ISO 8192, which is equivalent to OECD 209, a 30 -min EC20 > 1995 mg/L as determined (BASF AG, 1982).
Bringmann and Kühn (1977) studied the effect of DEG on the growth of Pseudomonas putida. They determined a 16 -h EC0 of 8000 mg/L.
It can be concluded that the inhibition of the degradation activity is not anticipated when the substance is introduced in appropriately low concentrations.
Species |
Results |
Remarks |
Reference |
Pseudomonas putida (growth inhibition) |
17-h EC10 = 69 mg/L (not neutralised; nominal) 17-h EC10 = 8070 mg/L (neutralised; nominal) |
Parent compound (DIBIS); reliability 4 (original reference not available) |
BUA (1991) |
Activated sludge, domestic (respiration inhibition) |
3-h EC50 > 1000 mg/L (nominal) |
OECD 209; hydrolysis product (DEG); reliability 2 |
Klecka et al. (1985) |
Activated sludge, domestic (respiration inhibition) |
30-min EC20 > 1995 mg/L (nominal) |
ISO 8192; hydrolysis product (DEG) reliability 2 |
BASF AG (1982) |
Pseudomonas putida (growth inhibition) |
16-h EC0 = 80000 mg/L (nominal) |
hydrolysis product (DEG), reliability 2 |
Bringmann & Kühn (1977) |
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