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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Principles of method if other than guideline:
To evaluate the primary irritation potential of the test materials, 0.5 mL of the undiluted test material was applied to the shaved backs of 6 New Zealand White rabbits. Exposure duration was 24 hours.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyl 2,3-epoxypropyl ether
EC Number:
219-376-4
EC Name:
Butyl 2,3-epoxypropyl ether
Cas Number:
2426-08-6
Molecular formula:
C7H14O2
IUPAC Name:
2-(butoxymethyl)oxirane
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
other: One abraded and one intact site was used on each animal.
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.5 mL
Duration of treatment / exposure:
24 hours
Observation period:
72 hours
Number of animals:
6
Details on study design:
The backs of the rabbits were shaved from shoulder to flank on the day preceding application. The treated areas were covered with Elastoplast coverlets and the rabbits were wrapped in elastic bandages. After exposure the skin sites were uncovered and scored for irritation; the patches were then replaces for an additional 20 hours. Readings were made again at 24 and 72 hours. The scoring method of Draize was followed.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24/72 h
Score:
1
Max. score:
4
Remarks on result:
other: intact skin
Irritation parameter:
edema score
Basis:
animal: #2, #3, #4, #5, #6
Time point:
other: 24/72 h
Score:
2
Max. score:
4
Remarks on result:
other: intact skin
Irritation parameter:
erythema score
Basis:
animal: #1, #4
Time point:
other: 24/72 h
Score:
1.5
Max. score:
4
Remarks on result:
other: intact skin
Irritation parameter:
erythema score
Basis:
animal: #2, #5, #6
Time point:
other: 24/72 h
Score:
2
Max. score:
4
Remarks on result:
other: intact skin
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 24/72 h
Score:
2.5
Max. score:
4
Remarks on result:
other: intact skin
Irritant / corrosive response data:
At 4 hours: There was negative to moderate irritation on intact skin and moderate to severe irritation on abraded skin, with no eschar present.
At 24 hours, there was moderate irritation on intact skin and severe irritation on abraded skin, with beginning eschar barely discernible in 2/6 rabbits.
At 72 hours, there was slight to severe irritation on intact skin and severe irritation on abraded skin, with eschar present in 5 animals.
The primary irritation score was 4.3 which classifies the substance as severely irritating. Escharotic for abraded skin.

Applicant's summary and conclusion