Registration Dossier
Registration Dossier
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EC number: 500-039-8 | CAS number: 25322-69-4 1 - 4.5 moles propoxylated
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No experimental data are available for ‘propane-1,2-diol, propoxylated’. However, for the structural analogues and constituents mono-, di- and tripropylene glycol data are available. Based on the lowest 72h-EC50 of >100 mg/L (for dipropylene glycol), it can be assumed that the 72h-EC50 for ‘propane-1,2-diol, propoxylated’ is > 100 mg/L. This is supported by calculations with ECOSAR v1.00 which indicate a 72h-EC50 value in the range 3000-4000mg/L based on modelling of the components and their likely composition
Key value for chemical safety assessment
Additional information
Monopropylene glycol:
Experimental data are available with fresh water and marine algae. In fresh water, the 96-h EC50 is 19,000 mg/l in Pseudokirchnerella subcapitata (reported as Selenastrum capricornutum) and the 14-d NOEC is 15,000 mg/l (ARCO Chemical Company, 1990). In marine water, the 96-h EC50 is 19,100 mg/l in Skeletonema costatum and the 14-d NOEC is <5300 mg/l (ARCO Chemical Company, 1990). The 14-day NOEC values cannot be used, since a NOEC should be a minimum value and the algae are not in the exponential growth phase anymore after 96 hours.
Dipropylene glycol:
A GLP compliant, OECD 201 guideline study is available for dipropylene glycol, measuring a 72-h EC50 and a 72-h NOEC value of >100 mg/l in the green algae Desmodesmus subspicatus (BASF, 2002).
Tripropylene glycol:
One non-GLP compliant guideline study (OECD 201) is available for tripropylene glycol. The 72-h EbC50 value and 72-h NOEbC value is >1,000 mg/l (nominal concentration) inPseudokirchnerella subcapitata(reported as Selenastrum capricornutum) (OECD, 1994). These values are used in the assessment.
QSAR:
A 96-h EC50 = 3000 -4000 mg/l was calculated using ECOSAR v1.11 based on modelling of the individual components.
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