Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-988-4 | CAS number: 504-29-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
- Principles of method if other than guideline:
- Data from peer reviewed handbook. No data provided on methods.
- GLP compliance:
- not specified
- Test type:
- other: not specified.
Test material
- Reference substance name:
- 2-pyridylamine
- EC Number:
- 207-988-4
- EC Name:
- 2-pyridylamine
- Cas Number:
- 504-29-0
- Molecular formula:
- C5H6N2
- IUPAC Name:
- pyridin-2-amine
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 500 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- EU criteria.
- Conclusions:
- The LD50 of the test item is ca. 500 mg/kg.
- Executive summary:
As reported in 'Patty's Toxicology', 6th edition (peer reviewed handbook data), dermal absorption in guinea pigs occurs readily for the test item, as indicated by an approximate LD50 of 500 mg/kg; deaths were accompanied by convulsions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
