N,N-dimethyl-3-(octadecyloxy)propylamine

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

7 July 2007 to 14 August 2007

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2007

Report date:

2007

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

N,N-dimethyl-3-(octadecyloxy)propylamine

EC Number:

241-516-8

EC Name:

N,N-dimethyl-3-(octadecyloxy)propylamine

Cas Number:

17517-01-0

Molecular formula:

C23H49NO

IUPAC Name:

dimethyl[3-(octadecyloxy)propyl]amine

impurity 1

Reference substance name:

Unknown impurities

IUPAC Name:

Unknown impurities

Test material form:

liquid

Results and discussion

Water solubility

Key result

Water solubility:

0 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

> 7.2 - < 7.6

Details on results:

On analysis of the definitive test solutions, a peak of similar magnitude to the very lowest standard concentrations and the sample responses was observed in the matrix blank solution. However no correction was made for this peak in calculations since the response was considered to be artificially elevated based on the excellent correlation of the linearity standards, and the overall limit value reported for the water solubility of the test material was determined from the nominal concentration of a standard solution with a response significantly above that observed for the matrix blank.

As negligible instrument response was observed for the definitive test sample solutions on analysis, the overall result for the water solubility of the test material was reported as a limit value. The limit value was based on the nominal test material standard concentration of 5.0 x 10^-3 mg/L which resulted in an instrument response of approximately for times higher than that observed for any sample solutions, and significantly higher than that observed for the problematic matrix blank. This value was then corrected for dilution factor (10), to give a final limit value of less than 5.0 x 10^-2 mg/L, equivalent to less than 5.0 x 10^-5 g/L of solution.

The column elution method should have been performed as the solubility was less than 1 x 10^-2 g/L. However, due to the physical nature of the test material, it was not possible to use this method; experience has shown that soft, waxy test materials coated onto glass beads cause these beads to compact and adhere together, forming a plug with the column and thus preventing water circulation.

Applicant's summary and conclusion

Conclusions:

The water solubility of the test material has been determined to be less than 5.0 x 10^-5 g/L of solution at 20.0±0.5ºC.

Executive summary:

The determination was carried out using the flask method, Method 105 of the OECD Guidelines for Testing of Chemicals.

 

Based on the preliminary result, 0.0257g, 0.0248g, and 0.0252g of test material and 500 mL of glass double-distilled water added to three separate flasks. They were shaken at approximately 30ºC and, after standing at 20ºC for a period of not less than 24 hours, the contents of the flasks were centrifuged at 13500 rpm for 20 minutes and filtered through 0.2 μm filters.

 

As negligible instrument response was observed for the definitive test sample solutions on analysis, the overall result for the water solubility of the test material was reported as a limit value.

 

The water solubility of the test material has been determined to be less than 5.0 x 10^-5 g/L of solution at 20.0±0.5ºC.