Registration Dossier
Registration Dossier
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EC number: 229-052-4 | CAS number: 6408-29-3
Endpoint summary
Administrative data
Description of key information
Not skin irritating
Eye Irrit. 2, H319
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), 3.2 Skin corrosion/irritation section, skin Irritation means the production of reversible damage to the skin following the application of a test substance for up to 4 hours.
The mean values from gradings at 24, 48 and 72 hours after patch removal were lower than 2.3 in all animals for both erythema/eschar and oedema reactions.
According to the Regulation 1272/2008 (CLP) substances that have the potential to induce reversible eye irritation are classified in Category 2 (irritating to eyes) if, when applied to the eye of an animal, a substance produces at least in 2 of 3 tested animals, a positive response of corneal opacity ≥ 1 and/or iritis ≥ 1, and/or conjunctival redness ≥ 2 and/or conjunctival oedema (chemosis) ≥ 2, calculated as the mean scores following grading at 24, 48 and 72 hours after installation of the test material, and which fully reverses within an observation period of 21 days.
The mean values from gradings at 24, 48 and 72 hours were:
- cornea score was equal/higher than 1 and lower than 3 in all the three animals tested;
- iris score was equal to 1 in all three rabbits;
- redness and oedema scores were equal/higher than 2 in all three rabbits.
All the reactions resulted to be reversible within 21 days.
In conclusion, the test substance is not classified for the skin irritation. On the contrary, it is classified as Eye. Irrit. 2 (H319), according to the CLP Regulation (EC 1272/2008).
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