Registration Dossier
Registration Dossier
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EC number: 217-614-1 | CAS number: 1908-87-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- In the Version dated 27-Jul-95
- Deviations:
- yes
- Remarks:
- see "Principles of method if other than guideline"
- Principles of method if other than guideline:
- - Ultra-pure water saturated with n-octanol was used for the stock solution instead of n-octanol saturated with water, because of an easier handling with higher volume accuracy. This had no effect on the
study.
- The shaking time was 23.5 hours instead of 24 hours. This had no effect on the study. - GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- mass spectrometry
- Key result
- Type:
- log Pow
- Partition coefficient:
- 0.59
- Temp.:
- 20.3
- Remarks on result:
- other: no information on pH available
- Conclusions:
- The GLP study was performed according to OECD TG 107 with acceptable deviations not affecting the study, the results were so obtained via a scientifically reasonable method. Hence, there is no doubt that the obtained results are not reliable: The partition coefficient was determined to be 0.59.
- Executive summary:
The partition coefficient of 3-Methyl-thiazolidin-thion-2 was determined in a GLP guideline study according to OECD 107 using the flask method. According to the definition of the OECD-Guideline 107 the test item shows a log Pow of 0.59 with a standard deviation of 0.03.
Reference
Description of key information
Partition coefficient: 0.59 [exp. result, OECD 107, flask method, GLP]
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.59
- at the temperature of:
- 20.3 °C
Additional information
The partition coefficient of 3-Methyl-thiazolidin-thion-2 was determined in a GLP guideline study according to OECD 107 using the flask method ( with acceptable deviations not affecting the study, the results were so obtained via a scientifically reasonable method). According to the definition of the OECD-Guideline 107 the test item shows a log Pow of 0.59 with a standard deviation of 0.03, not triggering any risks (log Pow < 3; e.g. regarding PBT Assessment).
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