Stoddard solvent

Sediment toxicity

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

sediment toxicity: long-term

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.

Qualifier:

according to guideline

Guideline:

other: QSAR model

Principles of method if other than guideline:

EPI Suite v 4.1/ECOSARv1.00

GLP compliance:

no

Remarks:

not applicable. QSAR model

Analytical monitoring:

not required

Vehicle:

no

Test organisms (species):

other: Earthworm

Details on test organisms:

no further information

Study type:

other: QSAR model

Test type:

other: QSAR model

Water media type:

freshwater

Type of sediment:

not specified

Limit test:

no

Duration:

14 d

Exposure phase:

total exposure duration

Hardness:

not applicable to QSAR models

Test temperature:

not applicable to QSAR models

pH:

not applicable to QSAR models

Dissolved oxygen:

not applicable to QSAR models

Salinity:

not applicable to QSAR models

Ammonia:

not applicable to QSAR models

Details on test conditions:

SMILES : CCCCCCCCCC
CHEM : Stoddard solvent
CAS Num: 8052-41-3
MOL FOR: C10 H22
MOL WT : 142.29
Log Kow: 5.252 (EPISuite Kowwin v1.68 Estimate)
Log Kow: 5.01 (PhysProp DB exp value - for comparison only)
Melt Pt: -29.70 (deg C, PhysProp DB exp value for Wat Sol est)
Wat Sol: 1.409 (mg/L, EPISuite WSKowwin v1.43 Estimate)
Wat Sol: 0.052 (mg/L, PhysProp DB exp value)

Reference substance (positive control):

no

Duration:

14 d

Dose descriptor:

LC50

Effect conc.:

113.787 mg/kg sediment dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: (Q)SAR prediction

Remarks on result:

other: non-toxic at the limit of solubility, as determined by (Q)SAR

Details on results:

LC50 (14-day, earthworm)= 113.787 mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 113.787 mg/kg soil dw
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 113.787 mg/L (ppm) for freshwater sediment.Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.

Overview of QSARs estimations on sediment toxicity of  

Stoddard solvent

Method	Results	Remarks	Reference
QSAR estimate	LC50 (14-day, earthworm)=113.787 mg/L (ppm)	Reliable with restrictions, QSAR estimated data	ECOSAR Program (v1.00)

 

   

LC50 (14-day, earthworm)= 113.787 mg/L (ppm)

 

Validity criteria fulfilled:

yes

Remarks:

US EPA accepted QSAR method for chemicals properties assessment.

Conclusions:

LC50 (14-day, earthworm)= 113.787  mg/L (ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
LC50 (14-day, earthworm)= 113.787 mg/kg soil dw
The ECOSAR QSAR model predicts that 14 -day LC50 value would to be 113.787 mg/L (ppm) for freshwater sediment.Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
.

Executive summary:

The ECOSAR QSAR model predicts that 14 -day LC50 value would to be  113.787   mg/L (ppm) for freshwater sediment.Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.

Reference 2

Endpoint:

sediment toxicity: long-term

Data waiving:

other justification

Justification for data waiving:

other:

Description of key information

The ECOSAR QSAR model predicts that 14 -day LC50 value would to be  113.787   mg/L (ppm) for freshwater sediment.Predicted to be non-toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.

Justification: Substance is a hydrocarbon UVCB. Standard tests for this endpoint are intended for single substances and are not appropriate for the risk assessment of this complex substance.

Key value for chemical safety assessment

EC50 or LC50 for freshwater sediment:

113.787 mg/kg sediment dw

EC50 or LC50 for marine water sediment:

11.38 mg/kg sediment dw

EC10, LC10 or NOEC for freshwater sediment:

22.76 mg/kg sediment dw

EC10, LC10 or NOEC for marine water sediment:

2.276 mg/kg sediment dw