Registration Dossier
Registration Dossier
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EC number: 248-324-3 | CAS number: 27206-35-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to microorganisms: EC0 ≥ 10000 mg/l, EC10 > 10000 mg/l, EC50 > 10000 mg/l over 16h for Pseudomonas putida (Safepharm Laboratories Standard Test Method 932.03 following the recommendations of the German Water Hazard Classification Scheme (Bewertung Wassergefährdender Stoffe LTWS - Nr 10) / ISO 10712 "Determination of the inhibitory effect of water constituents on bacteria (Pseudomonas cell multiplication inhibition test)"
Toxicity to microorganisms: EC0 ≥ 5 mg/l, NOEC ≥ 5 mg/l over 28 days for domestic sewage (OECD 301D)
Key value for chemical safety assessment
- EC50 for microorganisms:
- 10 000 mg/L
- EC10 or NOEC for microorganisms:
- 10 000 mg/L
Additional information
There are two studies available to cover this endpoint. One Klimisch 2 / ISO 10712 key study revealing the values EC0 ≥ 10000 mg/l, EC10 > 10000 mg/l, EC50 > 10000 mg/l (16h), and the toxicity control of a (for this endpoint) Klimisch 2 OECD 301D study revealing EC0, NOEC ≥ 5 mg/l (28d). The results are hence consistent (5mg/l was the only dose tested in the OECD 301D) and sufficiently reliable to assess the toxicity of SPS to microorganisms. The EC10 value of greater than 10000 mg/l corresponds to an evaluation number (Bewertungszahl, BWZ) for the German Water Hazard Classification Scheme of less than 2. With regard to the CLP Regulation 1272/2008, the results do not trigger classification of SPS as hazardous to the environment, as it isn't part of the classification criteria. In addition, it should be considered as harmless to the aquatic environment.
The database is of high quality, and the tonnage-driven data requirements under REACH are fully met, hence, no data gap was identified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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