Registration Dossier
Registration Dossier
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EC number: 445-760-8 | CAS number: 122886-55-9
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation
- Remarks:
- other: QSAR prediction
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- March 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted QSAR method using software mentioned in the REACH Guidance on Information Requirements and Chemical Safety Asessment. Respiratory sensitisation is a considered a reliable endpoint for QSAR assessment by DEREK NEXUS.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: QSAR report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Guidance document on the validation of (quantitative) structure-activity relationships models. OECD (September, 2007)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Guidance on information requirements and chemical safety assessment, Chapter R.6: QSAR and grouping of chemicals. ECHA (May 2008)
- Deviations:
- no
- Principles of method if other than guideline:
- DEREK Nexus version 5.0 was used to predict repiratory sensitisation properties of the three components that KY-EU contains.
- GLP compliance:
- no
Test material
- Reference substance name:
- KY-EU
- IUPAC Name:
- KY-EU
- Details on test material:
- - Name of test material (as cited in study report): KY-EU
Constituent 1
Results and discussion
- Results:
- DEREK analysis demonstrates no alerts for respiratory sensitisation present in the DEREK database for the three components that KY-EU contains.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Conclusions:
- Based on the absence of structural alerts for respiratory sensitisation for all three components that KY-EU contains, KY-EU is predicted to be not respiratory sensitising by DEREK Nexus version 5.0.
- Executive summary:
The (Q)SAR programme DEREK Nexus version 5.0 was used to predict respiratory sensitising properties of KY-EU. The default of DEREK Nexus version 5.0 fotr the level of likelyhood , mentioning an alert which is evaluated as being equivocal or greater was used.
No structural alerts were fired for all three components that KY-EU contains. Based on this result, KY-EU is predicted to have no respiratory sensitising properties.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
