2-propylheptyl methacrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2014

Report date:

2014

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

2-propylheptyl methacrylate

EC Number:

810-760-2

Cas Number:

149855-64-1

Molecular formula:

C14 H26 O2

IUPAC Name:

2-propylheptyl methacrylate

Constituent 2

Reference substance name:

2-Propylheptyl methacrylate

IUPAC Name:

2-Propylheptyl methacrylate

Details on test material:

- Name of test material (as cited in study report): 2-Propylheptyl methacrylate
- Physical state: liquid/ colorless, clear
- Analytical purity: 99.4 g/100 g
- Lot/batch No.: S731900107

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Wiga GmbH, Sulzfeld, Germany
- Age at study initiation: Young adult animals (approx. 10 weeks)
- Weight at study initiation: animals of comparable weight (+/- 20 %)
- Fasting period before study:
- Housing: single housing, Makrolon cage, type III
- Diet (e.g. ad libitum): ad libitum, VRF1(P); SDS Special Diets Services, 67122 Altrip, Germany)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +/- 3°C
- Humidity (%): 30 - 70 %
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

3 females (1 Administration)
3 females (2 Administration)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs, body weight, pathology:

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

No mortality occurred in both administration groups.

Clinical signs:

In the first 2000 mg/kg bw test group impaired general state and piloerection were observed from hour 0 or 1 until hour 5 in two animals, respectively. In the second test group impaired general state and piloerection were observed at hour 1 and 2 in one animal.
Three animals did not show any symptoms.

Body weight:

The mean body weight of the test groups increased throughout the study period within the normal range with three exceptions in both groups. One female of the first test group and two females of the second test group showed stagnation of body weight during the second week.

Gross pathology:

There were no macroscopic pathological findings in the animals sacrificed at the end of the observation period.

Any other information on results incl. tables

Mortality
Dose (mg/kg bw):	2000	2000
Sex:	female	female
Administration:	1	2
No. of animals	3	3
Mortality (animals):	No mortality	No mortality