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Diss Factsheets
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EC number: 410-510-9 | CAS number: 86753-82-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 87/302 , Part B OECD 414
- GLP compliance:
- yes
- Limit test:
- no
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Remarks:
- PEG 400
- Details on exposure:
- Method of administration or exposure: GavageMass median aerodynamic diameter:Not applicable
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Number of dams and doses24 at 0 mg/kg or mg/l24 at 50 mg/kg or mg/l24 at 200 mg/kg or mg/l24 at 1000 mg/kg or mg/l
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Details on maternal toxic effects:Treatment of pregnant females during day 6 to day 16 ofgestation inclusive, did not reveal any signs of maternaltoxocity.All mated females (except one) were pregnant and nodifferences were seen in the number of corpora lutea, thenumber of implantations, the pre- and post-implantation lossand the incidence of embryonic/foetal deaths.
Effect levels (maternal animals)
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- > 1 000 mg/kg bw/day
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Details on embryotoxic / teratogenic effects:Effects on fetus - Gross:No foetal deaths occurred among treated litters. Sex ratios were normal in litters of dams treated with substance.The total foetal weights and foetal weights of the sexes separately revealed no test substance-related changes.
Effects on fetus -
Soft tissue: There were no external findings that were concidered to have arisen as a result of treatment of dams with the substance. There were no morphological changes detected at visceral examination of the foetuses.
Skeletal: Skeletal examinations revealed no changes in the ossification of the foetal skeleton at dose up to 1000 mg/kg body weight/day. Treatment of dams at 1000 mg/kg/day slightly increased the incidences of supernumerary ribs and wavy ribs.
Effect levels (fetuses)
open allclose all
- Key result
- Dose descriptor:
- NOEL
- Effect level:
- 200 mg/kg bw/day
- Basis for effect level:
- other: embryotoxicity
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 1 000 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: no dose dependent effects except for slightly increased incidence of spontaneous variations at the highest dose.
Fetal abnormalities
open allclose all
- Abnormalities:
- effects observed, non-treatment-related
- Localisation:
- skeletal: supernumerary rib
- Description (incidence and severity):
- slight increase in incidence (frequent spontaneous variation)
- Abnormalities:
- effects observed, non-treatment-related
- Localisation:
- other: wavy rib
- Description (incidence and severity):
- silght increase in incidence (frequent spontaneous variation)
Overall developmental toxicity
- Developmental effects observed:
- yes
- Lowest effective dose / conc.:
- 1 000 mg/kg bw/day (nominal)
- Treatment related:
- no
- Relation to maternal toxicity:
- not specified
- Dose response relationship:
- no
- Relevant for humans:
- no
Applicant's summary and conclusion
- Conclusions:
- Based on the results in this embryotoxicity and teratogenicy study, the definitive No Observed Effect Level (NOEL) was established as being 200 mg/kg bw/day. The NOAEL was considered as 1000 mg/kg bw/ day.
- Executive summary:
Oral dosing of pregnant female Wistar rats with Hypersol synergist L 4722 at dose levels of 50, 200 or 1000 mg/kg bw/day during day 6 to 16 of gestation inclusive, was associated with a very slight increase in the total number of foetuses with supernumerary rib(s) or with wavy ribs, but there were no other indications of adverse effects upon in utero development of foetuses.
Based on the results in this embryotoxicity and teratogenicy study, the definitive No Observed Effect Level (NOEL) was established as being 200 mg/kg bw/day. The NOAEL was considered as 1000 mg/kg bw/ day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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