4,4'-sulphonyldiphenol

Bioaccumulation: aquatic / sediment

Administrative data

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study with acceptable restriction

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1998

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)

Deviations:

no

Principles of method if other than guideline:

NA

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

4,4'-sulphonyldiphenol

EC Number:

201-250-5

EC Name:

4,4'-sulphonyldiphenol

Cas Number:

80-09-1

Molecular formula:

C12H10O4S

IUPAC Name:

4,4'-sulfonyldiphenol

Details on test material:

NA

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
NA

Radiolabelling:

no

Sampling and analysis

Details on sampling:

NA

Test solutions

Vehicle:

not specified

Details on preparation of test solutions, spiked fish food or sediment:

NA

Test organisms

Test organisms (species):

Cyprinus carpio

Details on test organisms:

TEST ORGANISM
- Common name: Carp (Cyprinus carpio)
- Source: Sugishima fish farm, Japan
- Length at study initiation (lenght definition, mean, range and SD): ca. 10 cm
- Weight at study initiation (mean and range, SD): ca. 30 g
- Method of breeding: Pelleted feed for carp

ACCLIMATION
- Acclimation period: 28 days
- Acclimation conditions (same as test or not): 25 °C +/- 1 °C

Study design

Route of exposure:

aqueous

Test type:

flow-through

Water / sediment media type:

natural water: freshwater

Total exposure / uptake duration:

6 wk

Test conditions

Hardness:

NA

Test temperature:

25 °C +/- 2 °C

pH:

NA

Dissolved oxygen:

6 - 8 mg/L

TOC:

NA

Salinity:

NA

Details on test conditions:

- Test vessel:
- Material, size, headspace, fill volume: glass tanks of 100 liters in volume
- Type of flow-through (e.g. peristaltic or proportional diluter): Aquatron
- Renewal rate of test solution (frequency/flow rate): 200-800 ml/min
- No. of organisms per vessel: 15 - 20

Nominal and measured concentrations:

NA

Reference substance (positive control):

not specified

Details on estimation of bioconcentration:

NA

Results and discussion

Lipid content

Lipid content:

4 %

Time point:

start of exposure

Bioaccumulation factor

Bioaccumulation factor 1

Type:

BCF

Value:

< 2.2

Basis:

other: Concentration of test substance in fish, no further data available

Remarks on result:

other: Conc.in environment / dose:50 microg/L

Bioaccumulation factor 2

Type:

BCF

Value:

< 0.2

Basis:

other: Concentration of test substance in fish, no further data available

Remarks on result:

other: Conc.in environment / dose:500 microg/L

Details on kinetic parameters:

NA

Metabolites:

NA

Results with reference substance (positive control):

NA

Details on results:

NA

Reported statistics:

NA

Any other information on results incl. tables

NA

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

The BCF for the test susbtsnce was measured to be very low (< 0.2 and < 2.2 at test concentrations of 500 and 50 µg/L). Thus, a bioaccumulation of the test susbstance in aquatic organisms is not expected.

Executive summary:

Materials and methods

A Bioaccumulation study to fish was conducted according to OECD Guideline 305 C. The species Cyprinus carpio were exposed to the test substance.over a period of 6 weeks at test concentrations of 50 and 500 µg/L in a flow through system

Results and discussion

The BCF for the test susbtsnce was measured to be very low (< 0.2 and < 2.2 at test concentrations of 500 and 50 µg/L). Thus, a bioaccumulation of the test substance to aquatic organisms is not expected.