Registration Dossier
Registration Dossier
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EC number: 201-250-5 | CAS number: 80-09-1
Endpoint summary
Administrative data
Description of key information
Short -term toxicity
Short-term ecotoxicity data for freshwater at three trophic levels are available. The acute toxicity test showed that Daphnia is the most sensitive species with a EC50 of 55 mg/L.
The LC50 (96 h) to fish was indeed determined to be above the limit dose of 100 mg/L.
In a growth inibition test conducted with the green algaeDesmodesmus s.an EC50 (72 h) of 106 mg/L and a NOEC of 10.2 mg/L were derived.
Long-term toxicity
A NOEC (21 d) of 2.7 mg/L was derived in a reproduction test conducted withDaphnia magna.
A range finding early life stage test was conducted to assess the effects of DHDPSon the most critical and sensitive life-stages of a freshwater fishzebrafish(Danio rerio)and to target test concentrations for a definitive extended one generation reproduction test.
A NOEC for survival of ≥ 10 mg/L was derived. For growth impairment the NOEC was ≥ 10 mg/L
A zebrafish extended one generation reproduction test (ZEOGRT) was conducted to assess the potential effects of DHDPS on population-relevant apical endpoints and endocrine relevant mechanistic biomarkers during the exposure to the test item on different life stages andgenerations of the zebrafish (Danio rerio).
No test substance-related effects on endocrine relevant endpoints (fertility, fecundity, sex ratio, vitellogenin content, gonad maturity)were observed up to the highest tested concentration of 1250 µg/L.
There was no adverse treatment related effect on time to hatch and larval survival.
Male body length was statistically significantly reduced in the highest tested concentration in comparison to the control group when using Williams test one-sided. However, this reduction was minimal and the variation of body length in all test groups was high and
overlapped. Nebvertheless, as male body weight was the lowest in test group 5 (statistically not significant) and higher concentrations than 1250 μg/L have not been tested, this minor effect will be considered as worst-case scenario, resulting in a LOEC for male body length at1250 μg/L.
In conclusion the overall NOEC identified in this test was 250 μg/L (nominal concentration), the LOEC was 1250 μg/L (nominal concentration) based on reduced male body length. Since no other test substance-related effects on endocrine relevant endpoints were observed in this study up to the highest tested concentration of 1250 μg/L,this study does not indicate any
evidence of endocrine activity for DHDPS.
Activated Sludge
The EC10 of the test substance to activated sludge was tested to be 200 mg/L.
Additional information
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