Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-469-4 | CAS number: 121-44-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- TEA was investigated on male Wistar rats weighing 150-200 g. These were subjected to long-term poisoning by inhalation in 100-liter chambers, predetermined vapor concentrations being maintained around the clock for 3 months.
- GLP compliance:
- no
- Remarks:
- The study was conducted prior to the adoption of the OECD guidelines
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Triethylamine
- EC Number:
- 204-469-4
- EC Name:
- Triethylamine
- Cas Number:
- 121-44-8
- Molecular formula:
- C6H15N
- IUPAC Name:
- triethylamine
- Details on test material:
- CAS 121-44-8 (triethylamine), purity not indicated.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- not applicable
- Details on exposure:
- Rats were exposed by inhalation in 100-L chambers
- Duration of treatment / exposure:
- 30 and 90 days
- Frequency of treatment:
- daily
- Post exposure period:
- no
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1 and 10 mg/m3
Basis:
nominal conc.
- No. of animals per sex per dose:
- no data
- Control animals:
- yes, sham-exposed
- Positive control(s):
- no
Examinations
- Tissues and cell types examined:
- bone marrow cells
- Details of tissue and slide preparation:
- The preparation for cytological investigation were prepared by the method of Ford and Woolam (Ford C.E. and Woolam D.H. Stain technology, Vol.38, p.271, 1963).
- Evaluation criteria:
- The incidence of structural chromosome breakages and aneuploidy, recorded in metaphases of marrow cells, was used as the criterion of a mutagenic effect. The control was provided by the incidence of similar breakages in the marrow of intact rats of the same age and sex, maintained under identical conditions.
- Statistics:
- Student's test.
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- not examined
- Additional information on results:
- In the rats poisoned with TEA the incidence of cells with structural chromosome breakages did not exceed the control incidence (2%) in any experimental variant, but the incidence of aneuploid cells in the rats exposed to a concentration of 1 mg/m³ was significantly higher than in the controls 30 days after the beginning of poisoning (p<0.01). The incidence of hyperploid cells was similar to the control values in all the experimental groups except those subjected to long-term poisoning with 1 mg/m³ TEA for 30 days (p<0.01).
Rats poisoned with TEA did not exhibit any decrease of mitotic activity in the marrow during the observation period.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
TEA do not induce chromosomal breakages in the rat bone marrow cells. - Executive summary:
Male Wistar rats were exposed to 1 and 10 mg/cm³ triethylamine via continuous inhalation for 30 and 90 days. 50 to 100 bone marrow cells were scored per animal. The incidence of cells with chromosomal breakage did not exceed controls but the incidence of aneuploid cells was significantly higher at 1 mg/cm3 after 30 days. There was no incidence of aneupoidy in the dose group exposed to 10 mg/m³ of TEA neither after 30 days nor after 90 days of exposure. No decrease in mitotic activity was observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.