Triethylamine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1997

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: similar to guideline study, not GLP.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

COMPARATIVE ACUTE TOXICITY AND PRIMARY IRRITANCY OF VARIOUS CLASSES OF AMINES

Author:

Myers R. and B.Ballantyne

Year:

1997

Bibliographic source:

Toxic Substance Mechanisms 16:|151-193, (1997)

Reference 2

Reference Type:

other: USEPA TSCA 8(d) submission

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Remarks:

males only

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triethylamine

EC Number:

204-469-4

EC Name:

Triethylamine

Cas Number:

121-44-8

Molecular formula:

C6H15N

IUPAC Name:

triethylamine

Details on test material:

Triethylamine, no further data

Test animals

Species:

rabbit

Strain:

New Zealand Black

Sex:

male

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hrs

Doses:

0.5, 1.0 and 2.0 mL/kg bw

No. of animals per sex per dose:

4 males/group

Control animals:

not specified

Details on study design:

14 d observation period

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

580 mg/kg bw

Remarks on result:

other: The LD50 was reported as 0.794 mL/kg of body weight with 95% confidence limits of 0.486 to 1.30 mL/kg.

Mortality:

Mortality was observed within 2 weeks of dosing in 3 of the animals in the 1.0 ml/kg dose group and in 2 in the 2.0 ml/kg dose group

Clinical signs:

other: Clinical observations included necrosis of the skin and scab formation

Gross pathology:

Gross necropsy evaluation revealed darkening of the lungs and kidneys, mottled livers and pale livers and spleens.

Any other information on results incl. tables

The concentration in ml/kg/bw was converted into mg/kg/bw using density of test material of 0.73 g/mL.

Applicant's summary and conclusion

Interpretation of results:

highly toxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

After 24-hour exposure to the rabbit skin, triethylamine caused severe toxicity leading to death.

Executive summary:

Severe skin damage was was observed in New Zealand black rabbits. In dead rabbits, dark lungs and kidneys, pale liver and spleen and mottled liver were observed.