Registration Dossier
Registration Dossier
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EC number: 202-409-1 | CAS number: 95-31-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of Santocure NS vulcanization accelerator
- Author:
- Randall, D.J. and Bannister, R.M.,
- Year:
- 1 990
- Bibliographic source:
- Acute Toxic. Data 1 (2), 104-105
Materials and methods
- Principles of method if other than guideline:
- A 40 % suspension of Santocure NS vulcanization accelerator (N-tert-butylbenzothiazole-2-sulphenamide) in corn oil was applied for 24 hours directly to the clipped, intact skin of 2 (1 male/1 female) New Zealand albino rabbits at a dose of 7940 mg/kg bw using semi-occlusive dressings.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N-tert-butylbenzothiazole-2-sulphenamide
- EC Number:
- 202-409-1
- EC Name:
- N-tert-butylbenzothiazole-2-sulphenamide
- Cas Number:
- 95-31-8
- Molecular formula:
- C11H14N2S2
- IUPAC Name:
- N-(1,3-benzothiazol-2-ylsulfanyl)-2-methylpropan-2-amine
- Details on test material:
- Santocure NS
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Duration of exposure:
- 24 h
- Doses:
- 7940 mg/kg bw
- No. of animals per sex per dose:
- 2 animals per dose
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 940 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Signs of intoxication: none
- Mortality:
- No mortalities occured.
- Clinical signs:
- other: None.
- Gross pathology:
- Viscera of animals appeared normal at sacrifice.
Any other information on results incl. tables
Mortality: 0/1 male, 0/1 female, combined 0/2
Signs of intoxication: none
Survivors: 14 day, viscera appeared normal.
No mortalities occured. The dermal LD50 for Santocure NS vulcanization accelerator was greater than 7940 mg/kg bw. No obvious clinical signs were observed. Viscera of animals appeared normal at sacrifice.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 7940 mg/kg bw (rabbit).
- Executive summary:
A 40 % suspension of Santocure NS vulcanization accelerator (N-tert-butylbenzothiazole-2-sulphenamide) in corn oil was applied for 24 hours directly to the clipped, intact skin of 2 (1 male/1 female) New Zealand albino rabbits at a dose of 7940 mg/kg bw using semi-occlusive dressings.
No mortalities occured. No obvious clinical signs were observed. Viscera of animals appeared normal at sacrifice. The dermal LD50 for Santocure NS vulcanization accelerator was greater than 7940 mg/kg bw.
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