Butyllithium

Skin irritation / corrosion

Administrative data

Endpoint:

skin corrosion: in vitro / ex vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Study period:

2009-10-06

Reliability:

2 (reliable with restrictions)

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2009

Report date:

2009

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Corrositex TM is a quantitative in vitro corrosivity test. The model is based on the time required for the test substance to pass through a biobarrier membrane and produce a change in a chemical detection system.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Lithium hydroxide

EC Number:

215-183-4

EC Name:

Lithium hydroxide

Cas Number:

1310-65-2

IUPAC Name:

lithium hydroxide

Details on test material:

- Name of test material (as cited in study report): Lithium Hydroxide Anhydrous
- Molecular formula: LiOH;
- Molecular weight: 23.95 g/mol;
- Physical state: solid
- Analytical purity: 98 %;
- Purity test date: Not stated;
- Lot/batch No.: 1038 Dr. 107;
- Expiration date of the lot/batch: Not stated;
- Stability under test conditions: Stable at ambient conditions;
- Storage condition of test material: Not stated;

Test animals

Species:

other: n.a.

Strain:

other: n.a.

Details on test animals or test system and environmental conditions:

Not indicated; in vitro test;

Test system

Type of coverage:

other: n.a.

Preparation of test site:

other: n.a.

Vehicle:

other: n.a.

Controls:

no

Amount / concentration applied:

not indicated

Duration of treatment / exposure:

not indicated

Observation period:

not indicated

Number of animals:

not indicated

Details on study design:

The international Corrositex assay kit is an In vitro method for determining the corrosive potential of chemical substances. The results of this assay were used to determine the United Nations Transport Regulations Packaging Group. For detailed test procedure see Sect. "Any other information on materials and methods incl. tables"

Results and discussion

In vivo

Irritant / corrosive response data:

The results of the categorization screen indicated that the test article, Lithium Hydroxide Anhydrous, fell into category 1. For further Information, see Sect. "Remarks on results incl. tables and figures"

Other effects:

none

Any other information on results incl. tables

Two runs have been performed:

Run A:

Sample Nr.	1	2	3	4
Detection Time hr:min:sec	00:25:50	00:25:50	00:25:50	00:25.50
Start Time	00:00:00	00:00:48	00:01:55	00.02:57
CORROSITEX Time	00:25.50	00:25:02	00:23:55	00:22:53
Convert to Minutes	25.83	25.03	23.92	22.88
Mean of 4 Replicates	24.42

 

Run B:

Sample Nr.	1	2	3	4
Detection Time hr:min:sec	00:26:00	00:28:30	00:28:30	00:26.00
Start Time	00:04:36	00:05:43	00:06:52	00.07:50
CORROSITEX Time	00:21:24	00:22:47	00:21:38	00:18:10
Convert to Minutes	21.40	22.78	21.63	18.17
Mean of 4 Replicates	21.00

According to the results of the Corrositex TM Assay, the test article, Lithium Hydroxide Anhydrous, has to be classified as corrosive and allocated to packing group II according to the UN Dangerous Goods Transport Regulations

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: other: UN Dangerous Goods Transport Regulations

Conclusions:

Lithium hydroxide anhydrous was tested for corrosive properties in the Corrositex TM Assay which is used for assigning the packaging group according to UN Dangerous Goods Transport Regulations. Lithium Hydroxide Anhydrous was found to be corrosive and assigned to packing group II. Lithium hydroxide anhydrous has to be classified as corrosive Cat . 1B (H314) according to Regulation (EC) No 1272/2008 (CLP) and Corrosive R34 according to Directive 67/548/EEC.

Executive summary:

In accordance with column 2 of REACH Regulation 1907/2006/EC Annex VII section 8.1 in-vitro studies for skin corrosion and skin irritation do not need to be conducted if the available information indicates that the criteria are met for classification as corrosive to the skin or the substance is flammable in air at room temperature. n-Butyl lithium is pyrophoric and would react violently upon contact with water or air humidity, releasing flammable butane and corrosive lithium hydroxide, and likely starting a fire.

For classification, the results of CORROSITEX assays with Lithium hydroxide anhydrous and Lithium hydroxide monohydrate were considered. Gaseous butane is known to be not skin irritant.

In the following the test with Lithium hydroxide anhydrous is summarized:

Lithium hydroxide anhydrous was tested for corrosive properties in the Corrositex TM Assay which is used for assigning the packaging group according to UN Dangerous Goods Transport Regulations.

Lithium hydroxide anhydrous was found to be corrosive and assigned to packing group II.

Based on this data and as n-Butyl lithium reacts violently with water / air humidity to form butane and lithium hydroxide, this substance is also found to be

- corrosive: Cat . 1B (H314) according to Regulation (EC) No 1272/2008 (CLP) and

- corrosive (R34) according to Directive 67/548/EEC.