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EC number: 231-749-3 | CAS number: 7719-12-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Detailed publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Approach to long-term effects of phosphorus trichloride
- Author:
- He Y, Yang X, Zhong X, Deng L & Zhang J
- Year:
- 1 989
- Bibliographic source:
- Weisheng Dulixue Zazhi 3, 37-40
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Developmental toxicity study
- GLP compliance:
- no
- Remarks:
- : published study
- Limit test:
- no
Test material
- Reference substance name:
- Phosphorus trichloride
- EC Number:
- 231-749-3
- EC Name:
- Phosphorus trichloride
- Cas Number:
- 7719-12-2
- Molecular formula:
- Cl3P
- IUPAC Name:
- phosphorus trichloride
- Details on test material:
- Phosphorus trichloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Days 6-15
- Frequency of treatment:
- Daily
- Duration of test:
- Animals were sacrificed on Day 20
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0, 6.44, 9.7, 19.3 mg/kg bw
Basis:
actual ingested
- Control animals:
- other: positive + vehicle control groups
- Details on study design:
- Sex: female
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- 19.3 mg/kg bw/day
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Body weight gain of dams:
No effects in treated animals; reduction in positive controls
Effects on fertility: neg low med hig pos
Number of pregnant rats: 16 15 15 14 15
number of fetuses: 136 126 132 124 141
Corpora lutea: 218 205 217 206 150
corpora lutea per rat: 13.6 13.7 14.5 14.7 10
number of pups/litter: 8.13 7.73 8.47 8.06 8.2
dead fetuses: 3 1 3 10 0
% dead fetuses: 2.3 0.79 2.27 8.06 0
resorptions: 3 9 2 1 67
% resorptions: 2.2 7.1 1.52 0.81 47.5*
litters with resorptions:3 3 1 1 11
% Litter w. resorptions:12.3 20 6.67 7.14 73.3*
* = significant
neg low med hig pos
pups examined: 130 116 127 113 74
size (cm): 3,84 3.89 3.84 3.79 3,64
tail (cm): 1,29 1,29 1,25 1,25 1,13
weight of placenta (g): 0,43 0,49 0,46 0,47 0,51
frontal fontanella (mm): 3,14 2,95 3,06 2,97 2,93
There were no significant differences between treated and negative
control animals. No malformations were detected. Skeletal
development in treated foetuses was retarded but without a dose effect relation.
Positive controls showed clear effects on fertility indices but no malformations.
Applicant's summary and conclusion
- Conclusions:
- No evidence of developmentla toxicity or teratogenicity was seen under the conditions of this study.
- Executive summary:
No evidene of teratogenicity or developmental toxicity was seen in rats administered phosphorus trichloride on Days 6 -16 of gestation.
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