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EC number: 231-749-3 | CAS number: 7719-12-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, guideline comparable study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Principles of method if other than guideline:
- Mutation screening in S. typhimurium and S. cerevisae
- GLP compliance:
- no
- Remarks:
- : study pre-dates GLP
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Phosphorus trichloride
- EC Number:
- 231-749-3
- EC Name:
- Phosphorus trichloride
- Cas Number:
- 7719-12-2
- Molecular formula:
- Cl3P
- IUPAC Name:
- phosphorus trichloride
- Reference substance name:
- MCTR-190-77
- IUPAC Name:
- MCTR-190-77
- Details on test material:
- The test material is described as a colourless liquid
Constituent 1
Constituent 2
Method
- Target gene:
- Reversion to histidine independence (S. typhimurium)
Species / strainopen allclose all
- Species / strain / cell type:
- other: S. typhiumurium TA98, TA100, TA1535, TA1575, TA1538
- Details on mammalian cell type (if applicable):
- Not applicable
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- Saccharomyces cerevisiae
- Details on mammalian cell type (if applicable):
- Not applicable
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- Male Sprague-Dawley rat Arochlor 1254-induced liver S9 fraction
- Test concentrations with justification for top dose:
- The substance was tested in a range of concentrations ( 0.1-500 µl per plate), dissolved in distilled water.
- Vehicle / solvent:
- water or DMSO (both known to be nonmutagenic)
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- distilled water
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: For non activation assays the following substances were used as positive controls; Methylnitrosoguanidine, 2-Nitrofluorene (NF) and Quinacrine mustard (QM). For the activation assays; 2-Anthramine, 2-Acetylaminofluorene and 9-Aminoquinoline
- Details on test system and experimental conditions:
- The plates were incubated for 48 hours at 37 deg C.
- Evaluation criteria:
- The number of colonies on each plate were counted and recorded.
- Statistics:
- None stated
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: S. typhimurium TA98, TA100, TA1535, TA1537, TA1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks:
- All tests conducted with/without a metabolic system were negative.
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- The compound was toxic to the strains TA-1535, TA-1537, TA-1538 and TA-100 at 5 µL per plate.
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Species / strain:
- Saccharomyces cerevisiae
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks:
- All tests conducted with/without a metabolic system were negative.
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- Slight toxicity was observed at 5µL per plate with the strain D4.
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Additional information on results:
- No further information
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
The test compound was examined for mutagenic activity in a series of in vitro microbial assays employing Salmonella and Saccharomyces indicator organisms. The compound was tested directly and in the presence of liver microsomal enzyme preparations from Aroclor induced rats. The compound was tested over series of concentrations. The compound was toxic to the strains TA-1535, TA-1537, TA-1538 and TA-100 at concentration of 5µL per plate and higher. Slight toxicity was observed at 5 µL per plate with the strain D4. All the tests conducted with/without a metabolic system were negative for mutagenic activity. In conclusion, the test compound did not demonstrate any mutagenic activity in any of the assays conducted.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
The test compound did not demonstrate any mutagenic activity in any of the assays conducted - Executive summary:
The test substance was investigated for mutagencity in Salmonella typhimurium strains TA98, TA100, TA1535, TA1537 and TA1538; and in Saccharomyces cerevisae strain D4. Assays were performed using five concentrations of between 0.001 -5 ug/plate in the presence and absence of an exogenous metabolic acitvation system (Arochlor 1254 -induced male Sprague-Dawley rat liver S9 fraction). No evidence of mutagenicity was seen under the conditions of this study; toxicity was seen at the higher concentrations of the test material. Positive control compounds (MNNG, 2 -nitrofluorene, quinacrine mustard, 2 -anthramine, 2 -AAF and 8 -aminoquinoline) confirmed the sensitivity of the assay and the efficacy of the S9 fraction.
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