Registration Dossier
Registration Dossier
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EC number: 210-514-9 | CAS number: 617-48-1
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions.
- Author:
- Verrett, M.J., Scott, W.F., Reynaldo, E.F., Alterman, E.K., and Thomas, C.A.
- Year:
- 1 980
- Bibliographic source:
- Toxicology and Applied Pharmacology
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Although no formal guideline followed, the study is an accepted peer reviewed report
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- DL-malic acid
- EC Number:
- 210-514-9
- EC Name:
- DL-malic acid
- Cas Number:
- 617-48-1
- Molecular formula:
- C4H6O5
- IUPAC Name:
- malic acid
- Reference substance name:
- Hydroxy succinic acid
- IUPAC Name:
- Hydroxy succinic acid
Constituent 1
Constituent 2
Test animals
- Species:
- other: chick embryos
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOEL
- Effect level:
- > 10 other: mg/egg
- Based on:
- test mat.
- Basis for effect level:
- other: other:
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Details on embryotoxic / teratogenic effects:
Non teratogenic to chick embryos at upto 10 mg/egg
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
