Registration Dossier
Registration Dossier
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EC number: 210-514-9 | CAS number: 617-48-1
Endpoint summary
Administrative data
Description of key information
Additional information
In accordance with REACH Annex VII column 2, the hydrolysis study does not need to be conducted as the substance is readily biodegradable.
Malic acid is stable in water and will not hydrolyse or otherwise degrade to form hazardous or non-biodegradable metabolites
Read across to fumaric acid is considered valid as the metabolic route for fumaric acid is through malic acid. Therefore, to achieve biodegradation in excess of 60% implies that malic acid is also readily biodegradable. Fumaric acid is less water soluble and also requires one further metabolic step than malic acid; it is likely that malic acid biodegrades faster.
Modelling with EPISuite confirms high biodegradation for this class of natural substance.
D and L isomers of malic acid have the same metabolic profile (see toxicokinetic assessement)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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